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German Urban Lab publishes Hepatology article confirms the pig liver cells, able to have a life cycle after HBV invaion.

Release time:2013-09-28 16:28:25

In September of 2017, "Hepatology" officially published the research results of the team of professor Urban S. in the field of hepatitis B virus infection, confirming that hNTCP is a limiting factor in pig and monkey's hepatocytes. Meaning that going through the hNTCP overexpression, it supports the efficient infection of hepatitis B virus to pig and monkey hepatocyte, including the formation of cccDNA. The greatest academic significance of the result is that the limitation of primary hepatocyte models of hepatitis B virus infection and the limitation of animal models with a complete immune system are expected to be able to solved. Thereby promoting the development of hepatitis B virus drugs and the optimization of treatment strategies (link: http://onlinelibrary.wiley.com/doi/10.1002/hep.29112/abstract).

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